Promise of Bacillus thuringiensis
نویسندگان
چکیده
Bacillus thuringiensis crystal (Cry) proteins are the most widely used biological insecticides in the world. Their value in safely controlling insects that destroy crops and transmit human diseases is well established.Here, we reviewB. thuringiensisCry proteins as novel anthelmintics with a unique mode of action. In laboratory studies, Cry proteins are highly effective against a broad range of free-living roundworms and parasitic roundworms that infect plants and animals. Cry5B is therapeutic for two different intestinal roundworm parasitic infections – one in mice and the other in hamsters. The latter infection involves a minor hookworm parasite of humans, Ancylostoma ceylanicum, which is closely related to the more prevalent Ancylostoma duodenale. Therapy is observed despite the fact that much of the protein is likely degraded in the stomach prior to reaching the parasites. Cry21A is also therapeutic in mice infected with the roundworm parasite, Heligmosomoides bakeri. Cry proteins offer excellent combinatorial therapeutic properties with nicotinic acetylcholine receptor agonists – one of two classes of compounds approved by the World Health Organization for treatment of intestinal roundworms in humans. Given their nontoxicity to humans and their broad spectrum of nematicidal action, Cry proteins show great potential as next-generation anthelmintics.
منابع مشابه
Cry9Ca1 Toxin, a Bacillus thuringiensis Insecticidal Crystal Protein with High Activity against the Spruce Budworm (Choristoneura fumiferana)
The Cry9Ca1 toxin from Bacillus thuringiensis was significantly more toxic to spruce budworm (Choristoneura fumiferana) than the Cry1Ab6, Cry1Ba1, Cry1Ca2, Cry1Da1, Cry1Ea1, and Cry1Fa2 toxins. It displayed high activity against silkworm (Bombyx mori) but was not toxic to black army cutworm (Actebia fennica) or gypsy moth (Lymantria dispar). The Cry9Ca1 is the most effective spruce budworm toxi...
متن کاملThe Synergist Effect of The Henna Plant, Lawsonia alba on Bacillus thuringiensis var. kurstaki Against Third Larval Instar of Pistachio Leaf Borer, Ocneria terebinthina Strg. (Lep.: Lymanteriidae)
Ocneria terebinthina Strg. (Lep.: Lymanteriidae) is a leaf borer pest in pistachio orchard. The toxicity of Bacillus thuringiensis var. kurstaki alone and in combination with henna powder was investigated on third larval instar of O. terebinthina under laboratory conditions. Bioassay was carried out using spray technique on pistachio offshoot. Probit analysis of concentration-mortality data was...
متن کاملCry9Ca1 Toxin, a Bacillus thuringiensis Insecticidal Crystal Protein with High Activity against the Spruce Budworm (Choristoneura fumiferana).
The Cry9Ca1 toxin from Bacillus thuringiensis was significantly more toxic to spruce budworm (Choristoneura fumiferana) than the Cry1Ab6, Cry1Ba1, Cry1Ca2, Cry1Da1, Cry1Ea1, and Cry1Fa2 toxins. It displayed high activity against silkworm (Bombyx mori) but was not toxic to black army cutworm (Actebia fennica) or gypsy moth (Lymantria dispar). The Cry9Ca1 is the most effective spruce budworm toxi...
متن کاملبررسی حساسیت لاروهای سنین اول تا سومSpodoptera exigua (Hubner) نسبت به باکتریBacillus thuringiensis var. Kurstaki در شرایط گلخانه
In this study, susceptibility of the first three larval stages of Spodoptera exigua to Bacillus thuringiensis was investigated. To determine the LC50 values for each larval instar, 6 different logarithmic concentrations of Bacillus thuringiensis were used. A control was also included in each of the bioassays. The value of LC50 for 1st instar larvae, that had been treated one to four hours after...
متن کاملبررسی حساسیت لاروهای سنین اول تا سومSpodoptera exigua (Hubner) نسبت به باکتریBacillus thuringiensis var. Kurstaki در شرایط گلخانه
In this study, susceptibility of the first three larval stages of Spodoptera exigua to Bacillus thuringiensis was investigated. To determine the LC50 values for each larval instar, 6 different logarithmic concentrations of Bacillus thuringiensis were used. A control was also included in each of the bioassays. The value of LC50 for 1st instar larvae, that had been treated one to four hours after...
متن کامل